Origin and Occurrence of Human Chorionic Gonadotropin β-Subunit Core Fragment
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چکیده
منابع مشابه
EFFECT OF β-HUMAN CHORIONIC GONADOTROPIN (β-HCG) ON NEUTROPHIL FUNCTIONS
Many findings point to the presence of a close relationship between the immune, endocrine and neurologic systems. For example the suppressive effects of β-human chorionic gonadotropin (β-HCG) on IL-l production, the potentiative effect of enkephalins on lymphocyte functions and the suppressive effect of leuteinizing hormone (LH) on natural killer (NK) cell activities have been clearly esta...
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Human luteinizing hormone (hLH) and human chorionic gonadotropin (hCG) are human glycoprotein hormones each consisting of two subunits, an identical α-subunit and a unique β-subunit, that form noncovalent heterodimers. Structurally, β-hCG shares a high degree of sequence similarity with β-hLH, including a common N-glycosylation site at the N-terminus but differs mainly in the presence of an ext...
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The microheterogeneity property of hCG with regards to its sialic acid contents resulted in variable mobility of the glycoprotein in SDS-PAGE. The intact hCG molecule is composed of two dissimilar subunits, namely alpha- and beta-subunits. The identification of hCG bands in SDS-PAGE was accomplished by the immunoblotting experiment, whereby the antibody directed toward the specific region of be...
متن کاملHuman chorionic gonadotropin β subunit affects the expression of apoptosis-regulating factors in ovarian cancer.
Expression of human chorionic gonadotropin, especially its free β subunit (hCGβ) were shown to play an important role in cancer growth, invasion and metastasis. It is postulated that hCGβ is one of the factors determining cancer cell survival. To test this hypothesis, we applied two models: an in vitro model of ovarian cancer using OVCAR-3 and SKOV-3 cell lines transfected with the CGB5 gene an...
متن کاملB152 anti-hyperglycosylated human chorionic gonadotropin free β-Subunit. A new, possible treatment for cancer.
OBJECTIVE To investigate the ability of B152 to block cancer growth in cell lines in vivo and in nude mice in vitro. STUDY DESIGN We examined JAR, JEG-3, and NTERA trophoblastic cancer cell lines and KLE, Hec-1A, SCaBER, and T24 nontrophoblastic cancer cell lines. JEG-3 cells were transplanted into 8 nude mice. Four nude mice were administered B152 antibody, and 4 were administered control no...
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ژورنال
عنوان ژورنال: Molecular Endocrinology
سال: 1988
ISSN: 0888-8809,1944-9917
DOI: 10.1210/mend-2-9-825